When the show moved to The CW network after UPN merged with The WB network, MyNetwork TV (which was created to take over UPN's former affiliate stations) picked up the rights to air reruns of Girlfriends, although they eventually discontinued running them.

A representative from The CW stated that the network was going to cancel the series due to low ratings and that it would have been too expensive to re-enter production.

[10] "The Game", a 2006 episode of Girlfriends, features guest star Tia Mowry as Joan's cousin Melanie Barnett, an aspiring medical student who wants to give up her future to follow her professional athlete boyfriend to San Diego.

That episode was the launching pad for The Game, a spin-off series, which was canceled by The CW television network.

The new inception continues where it left off from the 2015 finale a few years later switching gears set in the new location of Las Vegas with the new protagonists of reprised characters, chronicling Tasha Mack and her struggles of being a woman of color sports agent; while her son Malik Wright learns to make important decisions in his sports career while quietly battling mental health issues and Brittany Pitts who is navigating her adult life taking on serious financial hardships and responsibilities becoming independent away from her Pro-Football dad's (Jason Pitts) image and inheritance.