He was born in Bologna, and began his career as a doctor and joined the medical faculty, where he assisted Vesalius in his dissections.
His son, Melchiorre Zoppio, would follow him into a dual academic and medical career.
He then returned to take up the chair in literature in Bologna, where he died Zoppio took an active part in the grammatical disputes that arose during his lifetime between the literary figures of Italy.
In Difesa del Petrarcha,[1] one of his pamphlets, Zoppio fiercely attacked Girolamo Muzio.
Fontanini pretended that this was because Muzio had said that philosophers were patriarchs to heretics,[2] but he could not find any other reason for Zoppio's attack, stating that its heat was inseparable from all discussion.