After training and the first professional steps, she had her first stage appearance in Berlin with Günther Lüders as a partner in the tabloid play Caution Brigitte, in which she showed her talent as a quick speaker.

[3] A year later, she played alongside Liesl Karlstadt and Karl Valentin in the well-known Berlin cabaret of comedians.

As a stage actress, Gisela Schlüter impressed with her versatility by dancing, singing, parodying and acting.

[5] Brigitte Mira as "Miese", however, had more sympathy with the audience than the "Liese" played by Gisela Schlüter, so that the Propaganda Ministry soon canceled the series as counterproductive.

[5] She also worked as a film actress, among others in We Dance Around the World (1939), The Tiger of Eschnapur (1937/38), A Night in May (1938), The Indian Tomb (1937/38), Six Days Home Leave (1941) and Our Auntie Is The Last (1973).

In the post-war period, along with many theater tours, she was the star of the Hamburg cabaret revue Faust, part three.

[9] Her long-term partner, the television writer Hans Hubberten, was closely connected to Schlüter's professional career.