[2] A third brother, Giovanni Andrea, was married to Gerolama Borgia, daughter of Pope Alexander VI, but both spouses died in 1483.

[4] He lived in a palazzo in the Pigna region of the city of Rome, which had been reconstructed from several family houses by his great-uncle, Cardinal Giuliano Cesarini, seniore.

On January 2, 1495, the King received all of the cardinals at the Palazzo San Marco, where he was lodged, with the exception of Carafa and Orsini, who were in attendance upon the Pope.

On May 27, 1495, Cesarini and nineteen other cardinals accompanied the Pope to Civitavecchia, then Orvieto, and then Perugia, in order to avoid problems that might arise from the further visit to Rome by Charles, now on the return journey from his war against Naples.

The papal Master of Ceremonies, Johann Burchard, notes in his Diary that he knew neither where nor how he was buried, since Bavano's padrone "was lacking in all goodness and humanity.

"[13] On 26 February 1500, there a grand reception was staged in Rome for Duke Valentino (Cesare Borgia) at the Porta del Popolo and a festive procession through the city to the Saint Peter's.

[14] Cesarini also participated in a similar ceremonial capacity in the investiture of Duke Valentino as Gonfaloniere of the Holy Roman Church and the award of the Golden Rose on Laetare Sunday, 29 March 1500.

Most Cardinals refused to approach the Papal Palace while Cesare was in charge, and were actually negotiating with the Castellan of the Castel S. Angelo to use that fortress as a secure place to hold the Conclave.

[17] Cesare, who in the meantime had decided to switch to the French side, was finally persuaded to vacate the Papal Palace and remove his troops.

As he was departing for the heights of Monte Mario on 2 September, and passing through the Garden Gate (Porta Vineae extra Portam Viridarii), he was accosted by Cardinal Cesarini, his sister's brother-in-law, who wanted to speak with Cesare.

But temperamentally Piccolomini was a temporizer, and the French hopes revived when Pius III granted Charles VIII permission to march his troops through Rome as he headed toward Naples.

Paris de Grassis, the Papal Master of Ceremonies, provided a comment at his death: vir alioqui formosus, grandis, pomposus, et totus in vita et virtute magnificus.