Dating from the 8th century, it is now used as the conventual church of the General Curia of the Clerics Regular Minor, the orders global headquarters.

The relics of St. Symphorosa and her seven sons were transferred to the Church of Sant'Angelo in Pescheria at Rome by Pope Stephen II in 752.

The inscriptions found in S. Angelo, a valuable source illustrating the history of the Basilica, have been collected and published by Vincenzo Forcella.

[3] In the second chapel to the left inside the church are frescoes of the Madonna with Child and Angels attributed to Benozzo Gozzoli (c. 1450).

During the late 14th century, Matteo de Baccari dedicated part of his inheritance to the Church of Sant'Angelo in Pescheria in Rome, specifically to the Chapel of St. Cosmo and Damian.