Engaged in the purchases of the Bank of Saint George, Giulio Sauli was repeatedly elected senator.

[1] He was elected doge on 12 October 1656, the sixty-eighth in two-year succession and the one hundred and thirteenth in republican history.

[1] Doge Giulio Sauli's two-year period was mainly marked by a new plague that affected the entire Ligurian region and which saw the interest of several nobles and the archbishop of Genoa Stefano Durazzo in works of charity and help to alleviate the sufferings of population.

[1] After the end of his mandate as Doge, on October 12, 1658, he continued to serve the Genoese state in other positions.

He died in Genoa in 1668 and was buried inside the Basilica di Santa Maria Assunta.