He established his studio at via Frugoni 15,[8] near via XX Settembre, where major urban development was taking place, involving prominent architects of the time such as Gino Coppedè, Luigi Rovelli, Benvenuto Pesce Maineri, Cesare Gamba, Dario Carbone, Gaetano Orzali, Stefano Cuneo, Raffaele Croce, Giuseppe Tallero, G. B. Carpineti, the Celle brothers, and others.
Cannovale arrived in the Ligurian capital at a critical time for the city, as the layout was changing and large residential districts were emerging.
At the beginning of the century, modern engineering technology was in its infancy, with numerous innovations emerging, the most important of which was the Hennebique system, or reinforced concrete.
[24] Cannovale began conceiving his projects with an entrepreneurial approach, becoming the exclusive licensee for Italy of the Wayss & Freytag cement production system, one of the first in the history of modern concrete construction.
[34] In 1910, he was the author of the renowned Teatro Eden in Genoa, the so-called "best known and most frequented among the variety venues", inaugurated in 1910 and built in the Louis XV style.
[37][38] From the mid-thirties, he was appointed president of STIG (Tolfetana Industrial Gypsum Company), headquartered on Lungotevere dei Mellini, while his engineering studio was located in central Piazza Cola di Rienzo, in the Prati rione.