A multifaceted figure, Gamba was a cultured man, politically engaged, a lover and scholar of foreign languages, and a devotee of various artistic interests.

His passion for music and theater led him to meet the most famous artists and musicians of the time, from Eleonora Duse to Sarah Bernhardt.

[3] Cesare Gamba's professional figure is mostly linked to the construction of Via XX Settembre in Genoa, a vast urban operation that saw him as an undisputed skilled protagonist in various aspects of the intervention (including Gino Coppedè, Benvenuto Pesce Maineri, Giuseppe Cannovale, Luigi Rovelli, Dario Carbone, Gaetano Orzali, Stefano Cuneo, Raffaele Croce, Giuseppe Tallero, G. B. Carpineti, the Celle brothers, and others): from financial to technical and design aspects.

The creation of a new road axis and the consequent arrangement of Piazza De Ferrari, the construction of the Monumental Bridge, and the connection between the Carignano area and that of the Acquasola, were the main interventions planned by the great urban transformation operation entrusted to engineer Gamba.

His wife Anna Cabella, in the plaque she had engraved at the Monumental Cemetery of Staglieno, remembered him with this inscription: "engineer, architect, rebuilder of his Genoa, artist, musician, high intellect and noble spirit, he preserved the heritage of integrity entrusted to him by his parents.