[specify] In 1684 he gained the lucrative post of Chierico della Camera Apostolica in the papal finance office; in 1688, he rose to become Treasurer General of the Holy Roman Church.
In the Consistory of 13 February 1690 he was made a Cardinal by Pope Alexander VIII, and was assigned the Deaconry of San Giorgio in Velabro on 10 April 1690.
[4] Clement in turn, rewarded Imperiali in 1701 by appointing him to the powerful position of Prefect of the Congregation of Buon Governo.
Renato's grand-uncle, Cardinal Lorenzo Imperiali, had amassed the nucleus of a collection of books in his Palazzo della Casa di Loreto in Campo Marzio.
The palace also contained artworks by the painters Carlo Maratta, Domenico Maria Muratori, and Francesco Ferrandi.
He enriched the library by buying collections from Jean Gautier de Sluse and monsignor Marcello Severoli in 1689-1690.