Giuseppe Santarelli (1710–1790) was an Italian castrato, composer, choir conductor, voice teacher, and Roman Catholic priest.
Born in Forlì, he entered a monastery in the Order of Saint Augustine at a young age where he was eventually ordained.
In 1749 he became a singer in the Sistine Chapel Choir in Vatican City, ultimately being appointed conductor in 1770.
In 1761 he published an essay on the organisation of the Sistine Chapel Choir, under the title: Informazione del Cantor Fra' Giuseppe Santarelli Cappellano d'onore dell'Eminentissimo e Reverendissimo Signor Cardinale Alessandro Albani come Ministro Plenipotenziario delle Loro MM.
In 1770 Santarelli met the English music historian Charles Burney who was touring France and Italy in 1770–1771.