In 1921 in an alliance with Esadists, Marka Gjoni founded the Republic of Mirdita in northern Albania and served as its president during its short existence.

Marka Gjoni fled to Yugoslavia, but later returned to Albania and remained active in the political life of the highlands.

He was often called upon to intervene in feuds raging within other Mirdita tribes and to preside over the arguments with fairness and clarity, but most of all to pass on judgments following the guidelines of the Kanun.

The gathering on May 29, 1928, at the vice-prefecture of Shpal, Mirdita, to renew the Covenant of the Besa was one of the major events that occurred under the leadership of Kapidan Gjon Marka Gjoni.

Upon the arrival of communism in Albania in 1944, Kapidan Gjon collaborated with his two eldest sons, Mark and Ndue, to organize the anti-communist resistance in the north.

[5] In Rome, Kapidan Gjon Marka Gjoni, collaborated with the Albanian publicist and writer Ernest Koliqi, in sketching a political organization in exile.