Its area included the Everglades, the Florida Keys, the Atlantic coast of Florida north through present-day Martin County and the Gulf coast north to Marco Island in Collier County.
It did not include the area around Lake Okeechobee, which was part of the Belle Glade culture.
At the time of first European contact, the Ten Thousand Islands district was part of the Calusa domain, the East Okeechobee district was occupied by the Jaega tribe, and the area of Broward and Miami-Dade counties was occupied by the Tequesta tribe.
The inhabitants of the Florida Keys were called Matecumbes by the Spanish, but it is not clear how distinct they were from the Tequesta.
It is identified as Glades primarily by the character of the sand and grit included in the clay used to form the pottery.