The architecture of the Gladstone is characterized by the rough-cut stone and brick, as well as by the dramatic arches over the windows and porch entrances.

In the hotel's Melody Bar, the two restored pillars' faux marble finish was rendered in true European fresco technique.

In addition to serving the three major railway companies, it also provided visitors attending the Canadian National Exhibition (CNE) with a place to stay.

[5] A report appeared in the Toronto Star on October 3, 1911, indicating that the Gladstone was soon to become the property of an incorporated company.

[6] Interviewed by the Star, Gianelli stated that the deal had not yet been closed, but the plan was to increase the size of the hotel and improve its facilities.

[15] The Zeidlers became sole owners of the hotel in 2003 and the venue began to host art shows, openings and community meetings, as well as live music.

Margaret Zeidler, who was involved in the restoration of 401 Richmond Street West,[16] had originally bought the hotel and made arrangements to have her sister manage it.

The owners invited local artists to compete in a competition for new designs for hotel rooms, each with a main concept or idea.

[4] The family provided financial support, and the employees at the hotel worked to find homes for the most elderly and at-risk.

Some of the former residents moved to the Parkview Arms Hotel, down Queen Street beside Trinity Bellwoods Park.

In 2004, the Gladstone began hosting Come Up To My Room, an alternative design exhibition showcasing new and established local art/design talent, co-founded and co-curated by Christina Zeidler and Pamila Matharu.

It was filmed over a span of five years, showing that the developers' plan for a gradual restoration with staff and residents remaining upstairs – while the bar served designer drinks to a new, affluent clientele downstairs – didn't work.

City inspectors demanded a complete rewiring, the boiler blew up leaving the hotel without heat, ceilings leaked, walls crumbled and management had to cope with this reality.