Gladstone Institutes is an American independent, non-profit biomedical research organization whose focus is to better understand, prevent, treat and cure cardiovascular, viral and neurological conditions such as heart failure, HIV/AIDS and Alzheimer's disease.

[2] Another focus at Gladstone is building on the development of induced pluripotent stem cell technology by one of its investigators, 2012 Nobel Laureate Shinya Yamanaka, to improve drug discovery, personalized medicine and tissue regeneration.

Gladstone Institutes was founded in 1979 as a research and training facility housed at San Francisco General Hospital.

[7] Dr. Mahley stepped down as president in 2010 to return to active research, and was replaced by R. Sanders Williams (former Dean of the School of Medicine at Duke University).

[23] The Institute of Virology has been involved in research regarding the COVID-19 virus, including its long-term effects on the heart,[24] and studying samples of SARS-CoV-2 variations appearing in California, and their resistances to the Moderna and Pfizer vaccines.

In addition, Gladstone investigators seek to accelerate the movement of basic science discoveries into clinical trials with efforts to bridge the so-called "Valley of Death".

Current research programs include: Another focus at Gladstone is building on the development of induced pluripotent stem cell technology by one of its senior investigators, 2012 Nobel Laureate Shinya Yamanaka.