[5] This area was a natural habitat and refuge for large water fowl populations that included ducks, geese, herons, egrets, ospreys and gulls.

The Native American tribes who resided in this area were the Costanoan people who spoke eight different languages which delineated between the various tribelets.

Another large parcel was the H&H Ship Service Facility of the Port of San Francisco, a toxic and hazardous materials site that had been ordered closed under the Resource Conservation and Recovery Act.

[12] Mission Bay was the original headquarters of the California Institute for Regenerative Medicine prior to the organization's move to Oakland.

The Caltrain commuter rail system connects Mission Bay with San Jose and Gilroy.

The Central Subway project linking Mission Bay to San Francisco Downtown and Chinatown opened in November 2022.

[28] Mission Bay has a large residential component with approximately 6,404 apartments and/or condos planned (1,806 of them to be designated affordable).