Langley Porter Clinic was the first psychiatric institute in California, and is the oldest facility of the UCSF Psychiatry Department.

In 1948, "the clinic's director, Karl Bowman, was transforming it into one of the world's most important hubs for research into transgender sexual identities."

Anthropologist Gregory Bateson, a former OSS officer; and poet Weldon Kees also worked here in the 1950s with psychiatrist Jurgen Ruesch.

[2] During WWII, Virginia Prince, a trans woman and pharmacologist who became "an early transgender activist" also worked at the clinic.

[3] Langley Porter Psychiatric Hospital relocated to a renovated space on the seventh floor of the UCSF Mount Zion Medical Center in 2023.