Situated underneath the South Pennell Road (PA-452) overpass in Middletown Township, Pennsylvania, it was originally built by the West Chester and Philadelphia Railroad, and later served the Pennsylvania Railroad's West Chester Branch, which finally became SEPTA's R3 line.

The station, along with all of those west of Elwyn, was closed in September 1986, due to deteriorating track conditions and Chester County's desire to expand facilities at Exton station on SEPTA's Paoli/Thorndale Line.

The Glen Riddle station still appears in publicly posted tariffs.

Resumption of SEPTA service to Wawa station does not include an intermediate stop at Glen Riddle, although the service restoration project provides for construction of a new station if demand warrants.

Media related to Glen Riddle (SEPTA station) at Wikimedia Commons