Holt started 24 games for the Kentucky Wildcats, totaling 88 career receptions for 810 yards and six touchdowns.

In Week 9 against the Buffalo Bills, Holt returned a kickoff 100 yards for a touchdown in the 2nd quarter.

On March 24, 2008, the Bengals re-signed Holt who was an exclusive rights free agent to a one-year contract.

A restricted free agent in the 2009 offseason, Holt was not tendered a contract offer by the Bengals.

[citation needed] In January 2020, Holt was working as Antonio Brown's trainer and was involved in an altercation with a delivery driver.