Since its inception, Global Exchange has enlisted thousands of members and supporters, by educating the U.S. public about what it thinks are the root causes of injustice and the impacts of U.S. government policies and corporate practices.

[6] Global Exchange was part of a coalition of groups that charged US retailers, including Gap, with illegally underpaying workers in their sweatshops in Saipan.

[9] The program, with an anti-Zionist focus, targets corporations that are directly involved in Israeli settlement activity in the occupied West Bank.

[15] Global Exchange Reality Tours organizes trips to over 30 countries in Latin America, Africa, Asia and the Middle East.

As part of their campaign to reduce oil consumption, on November 29, 2006, two protesters from Global Exchange and Rainforest Action Network, Mike Hudema and Matt Leonard, at the Greater Los Angeles Auto Show illegally disrupted a press stage where General Motors CEO Rick Wagoner was speaking and tried to get him to sign a pledge making GM the most fuel-efficient car company by 2010.

[16] The World Trade Organization has claimed that a number of websites such as the Global Exchange, etc., "contain accusations against the WTO which are based on incorrect information or downright falsehoods.

[18] It also says that Global Exchange appears to be spearheading former Venezuelan President Hugo Chavez's public relations efforts in the United States by offering reality tours for American tourists in Venezuela.