Glyptosaurinae is an extinct subfamily of anguid lizards that lived in the Northern Hemisphere during the Late Cretaceous and the Paleogene.

Glyptosaurines are known primarily from their osteoderms, scale-like pieces of bone that are embedded in the skin and cover much of their bodies.

The tissue forming the outermost layer of glyptosaurine osteoderms is similar to tooth enamel and has even been given its own name, osteodermine.

Below is a cladogram from Conrad and Norell (2008) showing the interrelationships of glyptosaurines and their relationship to other anguid lizards:[1] †Carusioidea Diploglossinae †Odaxosaurus piger †Proxestops jepseni †Xestops vagans †Paraplacosauriops quercyi †Peltosaurus granulosus †Arpadosaurus gazinorum †Melanosaurus maximus †Glyptosaurus sylvestris †Placosaurus rugosus †Proglyptosaurus huerfanensis †Paraglyptosaurus princeps †Helodermoides tuberculatus †Placosaurus estesi †Stenoplacosaurus mongoliensis Anguinae Gerrhonotinae The earliest known Glyptosaurines like Odaxosaurus are known from the Late Cretaceous (Campanian) of North America.

Glyptosaurines declined after the Mid-Eocene, become extinct in Europe by the end of the period as part of the "Grande Coupure".