Gmina Opoczno is an urban-rural gmina (administrative district) in Opoczno County, Łódź Voivodeship, in south-central Poland.

Its seat is the town of Opoczno, which lies approximately 72 kilometres (45 mi) south-east of the regional capital Łódź.

The gmina contains part of the protected area called Spała Landscape Park.

Apart from the town of Opoczno, Gmina Opoczno contains the villages and settlements of Adamów, Antoniów, Bielowice, Brzuśnia, Brzustówek, Brzustówek-Kolonia, Bukowiec Opoczyński, Dzielna, Janów Karwicki, Januszewice, Karwice, Kliny, Kraśnica, Kraszków, Kruszewiec, Kruszewiec PKP, Kruszewiec-Kolonia, Libiszów, Libiszów-Kolonia, Międzybórz, Modrzew, Modrzewek, Mroczków Gościnny, Ogonowice, Ostrów, Różanna, Sielec, Sitowa, Sobawiny, Stużno, Stużno-Kolonia, Wola Załężna, Wólka Karwicka, Wólka Karwicka-Kolonia, Wygnanów, Zameczek and Ziębów.

Gmina Opoczno is bordered by the gminas of Białaczów, Drzewica, Gielniów, Gowarczów, Inowłódz, Poświętne and Sławno.