Gnathostoma spinigerum is a parasitic nematode that causes gnathostomiasis in humans, also known as its clinical manifestations are creeping eruption, larva migrans, Yangtze edema, Choko-Fuschu Tua chid and wandering swelling.

[citation needed] The larval nematode is acquired by eating raw or undercooked fish and meat.

[3] Although Gnathostoma spinigerum are considered endemic to Thailand, they are also found in many other countries of Southeast Asia.

In Japan, freshwater fishes, Ophicephalus argus and O. tadianus, are the most important vectors of human gnathostomiasis.

On the other hand, there are other antihelminthic drugs available such as bithionol, thiabendazole, metronidazole, and others, that did not reveal any significant therapeutic effects in experimental G. spinigerum infections.