Golyama Brestnitsa (Bulgarian: Голяма Брестница) is a small hillside village in Yablanitsa Municipality, Lovech Province, northern Bulgaria.

Golyama Brestnitsa lies in a hilly country facing the Danubian Plain to the north and the foothills of the Balkan Mountains to the south.

From the Danchova Mogila hill near the village there is a panoramic view to the Balkan peaks of Dragoitsa, Lisets, Vasilyov and Vezhen to the south.

The closest major town is Botevgrad (37km) along the A2 towards Sofia There are numerous hikes and walks around the village and onward to Daben or Brestnitsa where the Saeva dupka caves.

The village has a lively café/pub/shop and square, picnic area, town hall with meeting room, post office with shop, church, cemetery and four B&B accommodations (guest house, room rental and villa rental).