Gonzaga Regional High School is an educational establishment located in St. John's, Newfoundland and Labrador, Canada.

In the 1973–1974 school year, a team from Gonzaga (Players: Gerry Beresford, Peter Chafe, Tom Harrington, Seth Reddy, alternate: Michael Bautista) won the national championship of the television quiz show Reach for the Top.

[5] The main tower of Gonzaga highschool is a 4-storey block of classrooms.

Administration offices, gymnasium, skilled trade workshop and adjoining music rooms (in former chapel) are located in the street level portion of the school set outside the footprint of the tower.

In 1987–1988, Gonzaga received major renovations and had multiple extensions built on adding a skilled trades workshop, drama rooms and no less than 12 new classrooms on the 4 floors.