Starring Hayley Mills as a teacher, the series takes place at the John F. Kennedy Junior High School in Indianapolis, Indiana.

The series was then integrated into the Saved by the Bell syndicated rerun package, with Miss Bliss episodes being introduced with a cold open by Mark-Paul Gosselaar (in character as Zack Morris) explaining that they were from an earlier time frame than the rest of the series, followed by a retrofitted version of the regular Saved by the Bell opening sequence.

On the first day of school, Miss Bliss (Hayley Mills) tries to help a student who she learns is having problems dealing with a situation involving his older brother dying.

Brian Austin Green as Adam Montcrief, Jaleel White as Bobby Wilson, and Jonathan Brandis as Michael Thompson were among some of the actors to appear in the pilot.

Other characters include Gabriel Damon as Bradley; Samantha Mills as Wendy; Julie Ronnie as Lonnie Maple; Matt Shakman as Georgie Winslow; Charles Siebert as Charlie Davis; Britton Elliott as Janet Hillhurst; Josh Goddard as Steven; and Andrea Messersmith as Laurie.

Intros by Mark-Paul Gosselaar, in character as Zack Morris, were added to the beginning of each episode, and the title sequence was remade in the style of Saved by the Bell.

The reflection in the animated sunglasses shows images of Bayside High and The Max, locations that were not present in the Indiana-set Good Morning, Miss Bliss.