Gordonville is a village in Cape Giradeau County, Missouri, United States.

The land around present-day Gordonville was originally owned by Sam Gordon and his father, who lived in Indiana.

The first church in the town was set up by Methodist missionaries on the farm of Louis Siemers in 1848, with Liberty School house being established shortly later.

In the 1850s, German immigrants began to move into the area and established farms around Gordonville.

In 2023 Mr. Crombie petitioned the village board of trustee's to rename the town Ville De Gordon, however it was voted down.

[7] According to the United States Census Bureau, the village has a total area of 0.78 square miles (2.02 km2), all land.

The racial makeup of the village was 99.23% White, 0.26% Black or African American, and 0.51% from two or more races.

The racial makeup of the village was 98.59% White, 0.94% Native American, and 0.47% from two or more races.