Medical College is situated in the suburban area of Vandanam, 9 km (5.6 mi) south of the Alappuzha (previously Alleppey) town, facing the NH 66, in Alappuzha district of Kerala State, South India.

N. V. Prabhu was the main driving force and founder of the T. D. Medical College, Alappuzha.

It is his brain child for he gave his heart and soul for building this private medical college, one of the first kind in the history of Kerala.

A total of 145 acres of land was purchased at Vandanam, in the coastal belt for the future development of the college campus, to include the hospitals, hostels, residential quarters.

Due to the objection raised by the Kerala University in running the medical college in this state collecting capitation fee from the students, the T.D.M.C.

As part of the plan for shifting the Medical College Hospital to the College Campus, the following five departments were shifted to the newly constructed hospital building (now it is Old Block I & II) at Neerkunnam near Vandanam, on 25 February 1991: Psychiatry, Dermatology & Venereology, Radiotherapy, Physical Medicine and Rehabilitation, Dentistry.

In 2005, the Pediatrics department was shifted to the newly constructed A & B block of Medical College Hospital Complex Vandanam.

In January 2007, Medicine and allied specialties have been shifted to new blocks such as D&E, I1, I2 IP wards at new hospital complex.

On 12 January 2010, the Chief Minister of the state finally proclaimed that the shifting of the Medical College Hospital from Alappuzha to Vandanam was completed.

Now the college and hospital are situated in a campus having an area of 162 acres and there is sufficient space for all types of future developments and there is a huge scope for developing this college as a Centre of Excellence in various fields of Modern Medicine.

The President of India, Shri Pranab Mukherjee, inaugurated the Golden Jubilee celebration of the T D Medical College at Alappuzha in Kerala on 16 March 2013.

After completion of the courses, the medical and nursing colleges separately organize the graduation ceremonies.