The Goya Award for Best Actress (Spanish: Premio Goya a la mejor interpretación femenina protagonista) is one of the Goya Awards, Spain's principal national film awards.
At the 1st Goya Awards ceremony held in 1987, Amparo Rivelles was the first winner of this award for her role as Laura in We Must Undo the House.
Carmen Maura has received the most awards in this category with three wins.
Penélope Cruz was nominated on twelve occasions, winning two times.
As of the 2025 ceremony, Carolina Yuste is the most recent winner in this category for her role as Mónica / Arantxa in Undercover.