Gran Madre di Dio (Great Mother of God) is a cardinal's titular church in Rome.

The monumental temple was built by Pope Pius XI in 1931, in memory of the celebrations held to commemorate the 1,500 anniversary of the Council of Ephesus, which established the dogma of the divine motherhood and her perpetual virginity of Mary, in the patristic tradition and popular devotion since From the Church.

It is the seat of the parish of the same name, erected by Pius XI on 1 December 1933, the year of Jubilee extraordinary redemption, in the Apostolic Constitution "Quo perennius" .

Exterior The main entrance is preceded by a portico with a triangular pediment supported by two columns with Corinthian capitals and side pillars.

semicircular apse has five arched windows, above which, within a frame, is the inscription SANCTA MARIA MATER DEI ORA PRO NOBIS (Holy Mary, Mother of God, pray for us).