Grand Island Senior High is the only high school in the Grand Island Public Schools (GIPS) system in Nebraska, United States.

The official mascot is the Islander, a tall man in a tropical grass skirt.

In 1955, a fourth building was constructed in the 2100 block of Lafayette Avenue and its predecessor became Walnut Junior High.

[4] GISH adopted an "academy" system for the 2019-2020 school year, making students choose one of five tracks to focus on.

[5] As a part of this system, Grand Island Senior High has expanded to three total campuses, including a technically focused Career Pathways Institute, and an education, law and public safety focused Wyandotte Learning Center.