It is part of the Grand Saline Independent School District located in northeast Van Zandt County.

In 1963 Grand Saline's Board of Education and the citizens approved the construction of a new high school, a new gymnasium and renovations to Person's Stadium.

Renovations would not come again until 1992, when GSISD voters approved a bond issue that built a cafetorium, a new parking lot, and additional classroom buildings to ease crowding.

The bond issue also added a student commons area which would connect the gymnasium and the classroom wings and create one building.

Grand Saline's Theater Department presents several shows each year, including Shakespeare and musical theatre.

Additionally, the theater department has a strong program in East Texas competing in numerous One Act play performances.

The Indians are coached by Joe Drennon, who won a Texas State Championship with rival Mineola High School in 2016.

Grand Saline Indian Football Tradition- GSHS also has strong traditions in Baseball, Softball, Tennis, and Track and Field.

Grand Saline and Van have the third longest streak in Texas High School Football history of playing each other every year, currently at 85 straight games.

Traditionally dominated in Football by Grand Saline and in Basketball by Edgewood, the rivalry continues to thrive as the two schools compete well against each other in all sports and in academic UIL.