The village is approximately three miles to the north-west of Stamford and very close to the county border with Lincolnshire (South Kesteven).

It passes to the east of Tickencote Warren, and at Exeter Gorse it briefly borders Horn, then meets Pickworth.

There is a very small nature reserve, Great Casterton Road Banks, to the south of the village containing examples of rare plants such as Sulphur Clover and Greater Broomrape.

Two miles north of the town are the earthwork remains of Woodhead Castle, a medieval moated ringwork with attached bailey.

The poet John Clare was married to Martha "Patty" Turner at Great Casterton church in 1820.