Founded in 2018, the airline launched operations with its first chartered and scheduled flights in June 2019.

[3] Established in 2018,[2] the airline offered charter flights for a range of Danish tour operators, initially with fleet of two 118-seat Embraer 195 aircraft bought from Stobart Air,[4][5] staffed by eight pilots and twelve cabin crew.

[8] The airline was initially co-owned by Thomas Hugo Møller and by Huy Duc Nguyen, who resigned from his position as a board member, executive and owner in March 2019 after a newspaper revealed exaggerations in his résumé.

[9] In March 2019, Eigild Bødker Christensen invested in Great Dane Airlines (via SEBC II ApS), leaving Great Dane Airlines co-owned by Thomas Hugo Møller (10%) and Eigild Bødker Christensen (90%).

[citation needed] On 11 October 2021, Great Dane Airlines filed for bankruptcy and ceased operations.