Great Falls Central Catholic High School is a private, Roman Catholic high school in Great Falls, Montana.

Great Falls Central Catholic was originally established in 1951 from a merger of St. Mary's High School, the Ursuline Academy for Girls and St. Thomas Home boarding school.

It closed in 1973 and the building was sold to the Great Falls Public Schools.

The school was reestablished at the University of Great Falls in 2001.

It moved to its current location when it was built in 2008.