Along with St. Patrick's Co-Cathedral in Billings, Montana it is the seat of the Diocese of Great Falls-Billings.

The first resident pastor was Father Dols, who was also responsible for parishes in Cascade, Choteau, and Neihart.

One of the first tasks of the new bishop, Mathias Clement Lenihan, was to build a new cathedral to accommodate the growing congregation.

[3][6] It features a cruciform plan, Gothic arched windows, and a turreted bell tower.

In 1995, Meadway & Stettner Pipe Organs of Monroe, Washington, refurbished the organ, which included adding front expression shutters to both chambers, console upgrades, and tonal revision while still remaining at 14 ranks.