It is located within the Roman Catholic Diocese of Great Falls-Billings and serves students from Crow and Northern Cheyenne tribes.

The founding of St. Labre Indian School in 1884 was one of the first efforts to care for Native Americans who had been displaced as a result of homesteading.

George Yoakum, a former soldier who had been stationed near Miles City, Montana, recognized the hard times experienced by the Northern Cheyenne.

He contacted John Brondel, Bishop of Helena, and told him of Native American people who were roaming the Tongue River Valley without homes or land—a reservation had not yet been set aside as their land.

The school has an unrated profile on Charity Navigator [2] and has found itself the subject of litigation (brought against it by the Northern Cheyenne Tribe).