A stone plaque on the west wall of the building records its construction at the expense of two donors.

Together with the nearby Scuola Canton, completed in 1532, it stands as a testament to the influence of the Ashkenazi community in the early years of the Ghetto, before the arrival of the much more affluent Jewish merchants from Spain and the Levant in the 1550s.

[9] Along with the other synagogues of Venice, it ceased to be regularly used in October 1917, when the local Jewish community was forced to disband;[a] at the same time, administration of all the Jewish places of worship was taken over by a single institution, the Templi Israelitici Uniti.

[11] Built on top of a preexisting structure, the prayer hall features an irregular shape.

[13] Media related to Scola Grande Tedesca (Venice) at Wikimedia Commons