Designed by Baldassare Longhena and Andrea Brustolon in a mix of the Baroque and Mannerist styles, the synagogue was completed in 1541.

[3] It is believed that Baldassare Longhena worked on the exterior of the building, and Andrea Brustolon on the interior, specifically the pulpit.

[4] The Levantine Synagogue is so named due to its founders being Eastern Sephardim from the Ottoman Empire as well as the Venetian colony of Corfu in what is now Greece.

[clarification needed] Only the windows, which are larger than a typical building's, stand out as different than the average dwelling, although the inside is far more intricate than the outside.

[7] Many external details are typical of Longhena's work, with a prominence of entablatures and volutes in the keystone, mirrored walls, the ashlar plinth, ovulate windows in the attic, and the doors' intricately carved decorations.