With a congregation established in 1550s, the synagogue was completed in the 1620s in what was, at the thime, the Habsburg monarchy, with the building named in honour of Rabbi Shmuel Eidels.

Abandoned in the 1940s, the synagogue was partially destroyed by the Nazis during World War II, and subsequently used by Soviet authorities as a warehouse.

Restoration efforts commenced in 2016 to preserve the former synagogue as a Jewish history museum.

"[3] During the Russo-Polish War of 1792, the Russian army under General Kakhovsky (according to Alexander Suvorov, but this is not true[citation needed]) approached Ostroh.

Meanwhile, the Polish army left the city, not ready to resist because of its small numbers.

Reconstruction of the ruins began in 2016 under the leadership of Hryhoriy Arshynov;[4][5] who died suddenly in 2020.