The city of Latrobe and the borough of Youngstown as well as Unity Township are within district boundaries.

Greater Latrobe School District encompasses approximately 69 square miles (180 km2).

According to 2005 local census data, it served a resident population of 29,134 people.

Students at the Senior High have the opportunity to attend the Eastern Westmoreland Career and Technology Center in Derry Township.

The district offers a variety of clubs, activities and sports.