[5] Greek Americans have the highest concentrations in the New York City,[6][7][8] Boston,[9] and Chicago[10] regions, but have settled in major metropolitan areas across the United States.

In 2000, Tarpon Springs, Florida, was home to the highest per capita representation of Greek Americans in the country (just over 10%).

Within the New York City region, Astoria, Queens contains an abundant Greek community and an official Greektown.

There are also strong Greek communities in Boston, the Salt Lake Valley, and in North Carolina, especially Charlotte and Asheville areas.

[12] Spanish and English historians mention three Greeks who sailed with Ferdinand Magellan in 1520 on his voyage to Patagonia.

[11] Another Greek, Don Doroteo Teodoro, was a sailor who landed in Boca Ciega Bay at the Jungle Prada site in present-day St. Petersburg, Florida with the Narváez expedition in 1528.

[13][14] He was instrumental in building the rafts that the expedition survivors built and sailed from present-day St. Mark's River in Florida until they were shipwrecked near Galveston Island, Texas.

[16] Don Doroteo Teodoro is regarded as the first Greek to have set foot on soil which is today part of the United States.

'Petros the Cretan', a Greek adventurer and soldier from Crete, is known for being a lieutenant of Francisco Pizarro who conquered the empire of Peru and founded the city of Lima.

[11] Ten years later, Thomas Cavendish met a Greek pilot by the name of Georgio, who knew the waters of Chile.

[17] Records show that a Greek, Michael Dry (Youris), became a naturalized citizen by act of the General Assembly of Maryland in 1725.

[16] Evstratii Delarov, a native of the Peloponnese,[16] was the first documented Greek explorer and merchant to arrive in Alaska.

Prominent American abolitionists Samuel Gridley Howe and Jonathan Peckham Miller participated in the Greek War.

Some of them were: Author Petros Mengous, Photius Fisk, Gregory Anthony Perdicaris, Evangelinos Apostolides Sophocles, George Colvocoresses, Garafilia Mohalbi.

In the American Civil War, Greek Americans fought for both sides, Union and Confederate, with prominent Greeks such as George Colvocoresses, John Celivergos Zachos and Photius Fisk taking part in the war on the side of the Union.

[28] During that period, most Greek immigrants to the New World came from Asia Minor and those Aegean Islands still under Ottoman rule.

Many Greek immigrants expected to work and return to their homeland after earning capital and dowries for their families.

The Greeks were de jure denaturalized from their homelands and lost the right to return, and their families were made refugees.

The events of the early 1920s also provided the stimulus for the first permanent national Greek American religious and civic organizations.

[32] Anti-immigrant sentiment, particularly among newspapers owned by William Randolph Hearst, provided the background to sensational trials in the 1920s, including the conviction of Alexander Pantages, Greek immigrant and movie theater pioneer, in 1929.

These later immigrants were less influenced by the powerful assimilation pressures of the 1920s and 1930s and revitalized Greek American identity, especially in areas such as Greek-language media.

In recent years, Greek immigration to the United States has been minimal; in fact, net migration has been towards Greece.

[36] In December 2022, the $85 million, newly rebuilt St. Nicholas Greek Orthodox Church opened in Lower Manhattan, 21 years after being destroyed in the September 11 attacks.

Atlantis editorial themes included naturalization, war relief, Greek-American business interests, and Greek religious unity.

[51] As of 2020[update], Ethnikos Kyrix (Greek: Εθνικός Κήρυξ, 1915–) is the only Greek-language daily publication based in the United States.

Headquartered in New York City, its articles focus on the Greek diaspora in the United States as well as current events in Greece and Cyprus.

[51][53] A companion weekly edition The National Herald (1997–) is in circulation and features similar content presented in English.