[3] The Houston Astros, parent club of Greeneville, withdrew their affiliate from the Appalachian League after the 2017 season.

[3] The Reds played their inaugural game on June 19, 2018, against the Bristol Pirates at Pioneer Park.

[6] Led by manager Gookie Dawkins,[7] Greeneville concluded their first season with a 28–40 record, placing fifth in the West Division, 15 games back.

[12] As of the completion of the 2020 season, one Greeneville Reds player had also played in at least one game for a Major League Baseball team.

Blake Trahan played four games on a minor league rehab assignment with Greeneville in 2019.