Tusculum is a city in Greene County, Tennessee, United States.

According to the United States Census Bureau, the city has a total area of 4.8 square miles (12.5 km2), all land.

[9] As of the 2020 United States census, there were 3,298 people, 641 households, and 461 families residing in the city.

At the 2000 census,[7] there were 2,004 people, 590 households and 437 families residing in the city.

23.1% of all households were made up of individuals, and 9.2% had someone living alone who was 65 years of age or older.

Tusculum has a branch post office located on the college campus.