Activities offered include speech & debate, basketball, golf, soccer, tennis, baseball, cross country, track & field, concert band, concert choir, cheerleading, Spanish club, math club, International Culture Club, National Honors Society, Science Olympiad, fencing, archery, and student council.

Soccer has been Greenwood's most notable sport since its inception in 1990 when it began as a club team.

[5] In the 1990s, boys soccer was coached by former Missouri State Bears player Jan Stahle, himself a Greenwood alum.

[5] From 1993 to 1997, Greenwood boys soccer made it to the State Championship round, placing 4th in 1993, 3rd in 1994, and 2nd in 1995–1997.

[5] During the 1996 season, Greenwood boys soccer had a national record of 23 consecutive shutouts.