Founded on 3 January 1926, the club played in the state football system before World War II.

After the war, all private sports clubs were shut down by the Soviet occupation in East Germany; the city was represented by state team BSG Einheit Greifswald (1946–1968) and nuclear plant team BSG KKW Greifswald (1968–1990).

[1] Greifswalder SC returned to the cup in 1993–94, losing by the same score at home to TSG Pfeddersheim upon entry in the second round.

[1] A year later, they won by that score at home to VfB Lübeck before losing by the same margin to Rot-Weiss Essen.

[1] FIFA World Cup winner Toni Kroos, a native of the city, played in the team's youth ranks from 1997 to 2002.