The team competed in the 500 cc class with Brazilian rider Alex Barros and a Honda NSR500V two-cylinder bike.

Barros ranked ninth in the final championship standings, and managed to record the team's first podium finish at Donington Park.

[1] In 1999, the team dropped down to the 250 cc class with a factory-supported Honda NSR250 and with reigning 250cc world champion Loris Capirossi as the rider.

Kato, who had already won two races as a wild-card racer in 1997 and 1998, made an instant impact with four consecutive podium finishes at the start of the season.

[4] In 2001, the team was renamed Telefónica Movistar Honda and former 125 cc world champion Emilio Alzamora was signed to replace Philippe.

[7] The team returned to the premier class in 2002 as Fortuna Honda Gresini with Kato as their sole rider.

[11] He also recorded the team's first ever pole position in the MotoGP class in the Pacific Grand Prix at Motegi, Japan.

[15] Kato remained with the team and became one of four Honda official riders, riding the latest 2003-spec RC211V, while Gibernau was given the modified 2002 bike.

[17] A week after Kato's death, Gibernau started from pole position and won the South African Grand Prix at Welkom, which marked the first race win for the Gresini team in the MotoGP class.

[20] Gibernau won three more races and recorded a total of ten podium finishes as he took the second place in the championship with 277 points.

Both riders remained with the team in 2007, albeit losing the Fortuna sponsorship due to European Tobacco Regulations.

Simoncelli was competitive at the top end of the field, but a number of crashes kept his points score low.

[26] For 2022, Aprilia re-entered the sport with their own factory team, taking incumbent riders Maverick Viñales and Espargaró.

Spanish rookie Fermín Aldeguer replaced the outgoing Marc Márquez at Gresini, who joined Ducati Corse, for 2025 and 2026.

Gresini rider Toni Elías won the inaugural Moto2 title on a Honda powered Moriwaki chassis.