Callie Torres (Sara Ramirez) and Arizona Robbins (Jessica Capshaw) co-parent their baby with Mark Sloan (Eric Dane) who continues to have an on/off relationship with Lexie Grey (Chyler Leigh).

Alex Karev (Justin Chambers) deals with the fallout of his decision to tell Owen about Meredith altering the Alzheimer's trial, and becomes an outcast by the other residents.

Teddy Altman (Kim Raver) marries Henry Burton (Scott Foley), who later dies of a heart condition, leaving her devastated.

In response to this, Meredith decides she will no longer pursue neurosurgery, and they agree that if they want to fix their relationship and have a chance of adopting Zola they cannot work together.

It is revealed that George failed his boards and was never seen again while Meredith turned Izzie in to her mother for her relationship with a patient, alluding to Denny (Jeffrey Dean Morgan), firing her.

Throughout the entire episode all the couples that actually do exist seem to have connections, which includes Callie and Arizona, and also Yang and Owen.

They discover that Lexie has had her lower abdomen and legs crushed under part of the plane, and she dies shortly after due to her injuries.

Derek was blown away from the scene of the crash, and he wakes up to find his hand trapped in a piece of metal pinning him to the ground.

Shortly after Derek returns to the site of the crash, they discover that Mark suffered internal injuries and Cristina must perform a surgical procedure on him with what they have on hand.

"[73] Verne Gay of Newsday acknowledged the following for the show stating, "Grey's has had a good season and has an intensely loyal fan base to prove it.

While she appreciated the "realism and authenticity that Grey's is known for", she found the episode was "almost too much" as it was "extremely gory and difficult to watch, initially because of the grisly wounds" but later because of the "heavy and emotional things that transpired".