[4] In 2022, she was nominated for the Children's and Family Emmy Award for Outstanding Voice Performance in an Animated Program for her work on The Loud House.

DeLisle was born in Fort Ord, California, to truck driver George Van Oosbree and singer Joanna Ruth,[2] and grew up in a Mexican-American household.

[8][9] DeLisle's mother became a born-again Pentecostal when she was eleven and she was later raised by her maternal grandmother, Eva Flores, a vocalist who performed with salsa musician Tito Puente.

She attended Chula Vista High School in the same graduating class as Mario Lopez.

In her late teens, she started singing old gospel tunes, and entered the world of comedy on the advice of a friend.

[13] Both DeLisle and Matthew Lillard, the current voice of Shaggy Rogers were upset about not being contacted about the decision to recast for their roles for the film.

[14][15] Around the time of the film's release, DeLisle said that she did not bear any hard feelings towards Seyfried or her performance in it.