It begins at Orange Drive (U.S. Route 27 or US 27) in Southwest Ranches and continues east to Federal Highway (US 1) in Dania Beach.

"[2] State Road 818 begins at the Flamingo Road (SR 823) intersection, paralleling the South New River Canal and heading east into a residential suburban area, forming the border between Davie to the north and Cooper City to the south.

Griffin Road continues east through Davie, having an interchange with Florida's Turnpike (SR 91) before a curve dips slightly south and away from the paralleling canal.

The road leaves Davie at the intersection with US 441/SR 7, entering a dense residential area of Hollywood.

Griffin Road then enters Dania Beach, retaining the dense residential areas until the interchange with I-95.