The film stars Baron Cohen, Mark Strong, Rebel Wilson, Isla Fisher, Annabelle Wallis, Gabourey Sidibe, Penélope Cruz, and Ian McShane.

After completing an interrogation, Sebastian gets information regarding philanthropist Rhonda George, who is hosting a benefit called WorldCure and is a potential target for assassination, and is assigned to go.

At the event, Sebastian sees hitman Pavel Lukashenko, who plans to assassinate Rhonda with a gun disguised as a video camera.

Chilcott and his men find the two brothers at a pub; they both manage to escape, though Sebastian is hit with two Lonomia poison darts in his shoulder and testicle.

Sebastian learns from Jodie that Lukashenko was going to make a deal with Joris Smit in a South African lodge, so the brothers travel there.

Lina tells them that Lukashenko purchased some sort of virus, but she is fatally shot by Chilcott's men from a distance before she can reveal any further information.

Rhonda, the real mastermind of the plot, visits Sebastian and tells him her plans to launch the virus (called WorldCure) into the arena via fireworks.

In October 2013, Sacha Baron Cohen was spotted attending a football match between Grimsby Town and Cambridge United.

Baron Cohen, who was dressed in a Grimsby shirt, was also spotted talking with Town fans in a nearby pub after the game.

[12] On 24 April 2014, Mark Strong joined the film to play a British black-ops spy and brother of Baron Cohen's character.

[9] On 11 June, Ian McShane, Gabourey Sidibe, David Harewood, and Johnny Vegas were confirmed as cast members.

[8] Principal photography of the film commenced on 4 June 2014, at North Weald railway station, and around the Epping Forest area in Essex, England.

[18] A number of residents of Grimsby were upset with Baron Cohen for negative stereotypes portraying their town as a rubbish-strewn, violent ghetto in which drunks urinate from windows and mothers hand children cans of beer in the street.

[4] In the United States and Canada, the film opened on 11 March 2016 alongside 10 Cloverfield Lane, The Young Messiah and The Perfect Match.

The website's critical consensus reads, "The Brothers Grimsby showers viewers with a steady stream of Sacha Baron Cohen's edgy humor, but too many gags hit the wrong side of the line between audacious and desperate.